cell senescence การใช้

• May contribute to tumorigenesis by suppressing p53 / TP53-induced cancer cell senescence.
• Nicotinamide riboside prevents muscle, neural and melanocyte stem cell senescence.
• During mammalian development multiple cells undergo programmed cell senescence and are then phagocytosed by macrophages.
• Through its association with cell senescence in epithelial cells, EndoG may also contribute to age-related vascular diseases such as arteriosclerosis.
• Other aberrations in cell cycle dynamics influence cell senescence, oxidative stress, and misregulated apoptosis ( Franco et al ., 2006 ).
• Oxidative stress results when ethanol induces NOX expression, resulting in ROS production in osteoblasts which can untimately result in cell senescence.
• His two new mentors formed a longstanding research team with an interest in cell senescence and its flip side, the immortality of cancer cells.
• As a bioactive lipid, ceramide has been implicated in a variety of physiological functions including apoptosis, cell growth arrest, differentiation, cell senescence, cell migration and adhesion.
• A husband-and wife-research team at Baylor, Dr . James Smith and Dr . Olivia Pereira-Smith, discovered the gene while working on cell senescence, the study of why cells stop reproducing.
• He said, ` Do you think we could get you interested in a problem called cell senescence ?'The funny thing is, he didn't think senescence had anything to do with aging ."
• Second, if the telomere shortening system evolved in humans as a last-ditch defense against cancer, as seems probable, any intervention that paralyzes the system will postpone cell senescence at the high price of encouraging cancer.
• Despite some scientists'euphoric talk about the discovery of a cellular " fountain of youth, " however, others cautioned that the cell senescence mechanism is also a principal defense against cancer, and that bypassing it could be dangerous.
• The conference featured hundreds of workshops and sessions, including highly technical ones on such topics as the " Role of Telomeres in Cell Senescence, " and " Do Genes Regulating Apoptosis Contribute to Longevity in Humans ?"
• In experimental mouse models, loss of DNA damage response-mediated cell senescence was observed after using a short hairpin RNA ( shRNA ) to inhibit the double-strand break response kinase ataxia telangiectasia ( ATM ), leading to increased tumor size and invasiveness.